Resveratrol (3,5,4′-trihydroxystilbene) protects pregnant mother and fetus from the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin

Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent, bioaccumulative and toxic contaminant widely distributed in the environment. Fishes are the most sensitive vertebrates to TCDD, especially during their early developmental stages. TCDD induces various toxic effects including yolk sac edema, craniofacial malformation and neural damage in developing fish embryos. However, the effects of ...

2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Pathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.

The technical chlorophenols and products produced from them, such as the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) have been found to contain chlorodibenzo-pdioxins such as 2,3,7,8-tetrachlorodibenzo-pdioxin (TC-DD). TCDD and other chlorodibenzo-p-dioxins are among the most toxic compounds known, and have been implicated in outbreaks of chloracne among chemical workers (1). Hepatic ...

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin upon hemostasis and hematologic function in the rat.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been identified as a toxic contaminant of chlorophenols and related hydrocarbons that are widely used in agriculture and industry. It has been implicated in various diseases, including human cases of chloracne (1) and porphyria cutanea tarda (2) and in chick edema (3). Its teratogenicity has been documented in rats (4) and mice (5). Monkeys fed tox...

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.

It has been reported (1) that one effect of a single, intra-peritoneal dose of 2,3,7,8tetrachlorodibenzo-p-dioxin (dioxin) is to cause a reduction in the duration of action of the drug 2-amino-5-chlorobenzoxazole (zoxazolamine) in the rat. This effect is maximal with doses of dioxin above 100J,g/ kg and significant even at 5 jug/kg. Our own work showed that oral dosage had a similar effect but ...